List of 10 Best Senolytic Supplements for 2022

  Reviewed
 by Dr. Steve Hruby, D.C.
Reviewed by Dr. Steve Hruby, D.C.

SuperHumans are the toughest, fittest, healthiest and happiest human beings on this planet. My mission is to help you realize your superhuman potential and learn how to live a long, happy and healthy life.

  Fact Checked
 by Rhealyn Tropia, RMT
Reviewed by Rhealyn Tropia, RMT

I’m a content organizer, fact-checker and super mom who ensures content is medically-reviewed, highly accurate, and engaging. My passion is organizing information and ensuring the facts are presented in a manner that is interesting and easy to understand.

senolytic supplements

The human race’s fascination with youth and longevity has never been under wraps. Numerous studies have been conducted time and again to find substances that can fight aging and offer humankind the gift of better health and greater vitality.

Senotheraphy is the latest revolutionary study that shows promising results against aging and age-related diseases.

Senolytics are a class of drugs that are said to induce the death of senescent cells, which are linked to aging. Senescent cells are associated with crucial life functions earlier in life. Later in life, they stop diving, causing many age-related afflictions.

There are several senolytic supplements on the market that claim to fight the signs of aging, but finding the right one is a daunting task.

In this blog, we are going to help you understand senolytics and its benefits. We have also enlisted ten of the best senolytic supplements to choose from!

Senolytic Activator: What Is It?

Healthy cells of our body perform wound repair, embryonic tissue development, and many other crucial functions during their early life. But over time, these cells age and stop dividing.

As a result, these cells (called senescent cells) also start to accumulate in our body, affecting the day-to-day function of the surrounding healthy cells. This cellular level senescence is considered a natural part of the aging process.

Senolytic activators are anti aging supplements or compoundsthat selectively target these senescent cells. That means they eliminate the senescent cells without causing any damage to the surrounding healthy cells.

This could lead to an increased overall lifespan by delaying the onset of age-related diseases and illnesses including atherosclerosis, heart disease, osteoarthritis, osteoporosis, heart attacks, sarcopenia, emphysema, metabolic disorders, neurodegenerative disorders, stroke, hearing loss, vision loss, blood vessel disorder, vertebral disk degeneration, cancer and more.

In short, senolytic compounds could prove to be the best supplements to take for optimal health and to enjoy a healthier and longer lifespan.

Senolytic Supplements: Top 10 Products

We have done extensive research and enlisted ten of the best senolytic supplements currently available on the market so that you don’t have to!

1. Life Extension Senolytic Activator

Features:

  • Ingredients: Combines plan-derived flavonoid apigenin, black tea theaflavins and ultra-absorbable forms of bio-flavonoids fisetin and quercetin.
  • Quality: Sourced using pure and potent raw ingredients that are of the finest quality.
  • Safety and Purity: Gluten-free, non-GMO formula.
  • Manufacturing: Made to the highest standards in the USA.

Pros:

  • Helps manage senescent cells
  • Easy once-a-week dosage
  • Promotes healthy cellular function and youthfulness
  • Supports longevity and systemic rejuvenation
  • Supports immune system

Cons:

  • Some people complain of having intolerance to the product

2. Double Wood Fisetin Capsules

This is one of the best polyphenol supplements as it contains 100 mg of pure fisetin (per capsule) which is a powerful polyphenol flavonoid that supports healthy aging.

Features:

  • Ingredients: Contains fisetin, which is a powerful polyphenol that clears damaged and potentially harmful cells and supports healthy aging. Other ingredients used are veggie capsules (Hypromellose), cellulose and rice flour.
  • Safety and Purity: Vegan, gluten-free, non-GMO.
  • Manufacturing practice: Manufactured and tested in the USA.

Pros:

  • Fisetin is a powerful antioxidant that helps support blood pressure, heart health, skin health, bone health, cholesterol and cognitive function
  • Supports healthy aging
  • Supports brain health, circulation, and organ health

Cons:

  • Not recommended for pregnant women or nursing moms
  • Fisetin can cause side effects such as nausea, mild insomnia, headaches or skin irritation in some

3. Supersmart – Senolytic Complex

Features:

  • Ingredients: Combines Bromelin (2000 GDU/g), Quercetin, Fisetin from Rhus succedanea stem, and NMN. These capsules also contain vitamin C (ester C), extract of decaffeinated black tea leaves, acacia gum and white rice.
  • Supports anti-aging: Encourage self-destruction of senescent cells that are responsible for aging and age-related health concerns.
  • High quality: It contains quercetin phytosome, which is said to be 20 times more absorbable than standard quercetin.
  • Money back guarantee: The brand offers a one year guarantee on the product. If you are not satisfied with the supplement, you can get a refund.
  • Safety and Purity: This senolytic complex is vegan-friendly, non-GMO, gluten-free and free from preservatives.

Pros:

  • Good for maintaining optimal health
  • Might extend life expectancy
  • Helps delay the aging process and fight age-related health concerns
  • Claims to provide a rapid and long-lasting rejuvenating effect
  • Boosts immune system
  • Lowers blood fat levels

Cons:

  • Not recommended for pregnant and breastfeeding women

4. Sharoaid Liposomal Fisetin

Features:

  • Ingredients: Contains Fisetin and Quercetin, the combination of which is said to work wonders for anti-aging or healthy aging. Each serving of the product equals 200 mg of quercetin and 1000 mg of fisetin.
  • Purity: It makes use of 98% pure fisetin.
  • Efficacy: Liposomal fisetin combined with quercetin has greater bioavailability. Liposomal technology ensures direct absorption of the supplement by the cells for better functioning and faster benefits.
  • Safety and Purity: Non-GMO, gluten-free, soy-free, and sugar-free.
  • Manufacturing: Sharoaid liposomal fisetin is manufactured in the UK under strict quality measures and high-quality raw materials.

Pros:

  • Supports good heart health
  • Scavenge senescent cells
  • Boosts memory and cognition
  • Supports immunity
  • Boosts energy
  • Comes in easy to swallow softgel form

Cons:

  • May cause side effects for some
  • No third party test certificate provided on Amazon

5. Healthycell Telomere Length

Features:

  • Ingredients: Clinically proven rainforest extract, AC-11, coenzymated vitamins and antioxidants.
  • Efficacy: AC-11 is an exclusive bioactive rainforest extract that is research proven to enhance cell health. The combination of this herbal extract with other potent ingredients aids the anti-aging process by boosting telomerase enzyme production.
  • AC-11 together with zinc repair cellular DNA and essential coenzymes vitamins 5-MTHF and Methylcobalamin reduce homocysteine (the elevated levels of which causes heart disease, dementia and stroke).
  • This product optimizes key processes such as DNA repair, Telomerase Activation, Homocysteine Reduction, and Nitric Oxide Production that impact telomere length.
  • Formula by: The product is formulated by leading stem cell researcher and Nobel prize nominee, Vincent Giampapa, MD.
  • Safety and Purity: These capsules are free of GMOs, allergens, artificial additives, binder, fibers, flow agents, coatings, soy, and gluten.

Pros:

  • Optimizes cell health
  • Bioactive phytonutrients support the length of telomeres that maintain telomere levels and repair cellular DNA
  • Helps boost the release of nitric oxide to maintain telomere length
  • Reduces homocysteine
  • Responsibly sourced

Cons:

  • Has a strong taste and odor

6. Humanx Fisetin Supplement

Features:

  • Ingredients: This is a 98% pure fisetin supplement
  • Function: Fisetin helps cells function optimally by protecting them from stress related damage. Fisetin is a senolytic activator that also helps produce the most powerful antioxidant in the body i.e., glutathione.
  • Benefits: Fisetin is effective in removing senescent cells from the body which are the prime cause of aging.
  • Money back guarantee: If you aren’t satisfied with the product, you can get a full refund.
  • Manufacture: This is a GMP certified product that is manufactured and tested in the USA under the highest regulatory standards.
  • Safety: This is a vegan, non-GMO, keto-friendly, plant based product that is free from artificial flavors, binder, magnesium stearate, allergens, lactose, and soy.

Pros:

  • Promotes cognitive function
  • Eliminates senescent cells
  • Promotes brain wellness
  • Promotes longevity
  • Powerful antioxidant

7. Life Extension Bio-Fisetin

Bio-fisetin supplement with up to 25 times greater bioavailability.

Features:

  • Ingredients: This product combines fisetin with galactomannan fibers (coming from fenugreek seeds) for increased bioavailability.
  • Function: Fisetin is an excellent senolytic agent that is broken down inside the body into inactive metabolites during digestion. This makes us lose out on most of the health benefits of fisetin. With its advanced delivery technique, this formula circulates for a longer duration in our system so that our body has more time to make use of all the health benefits of fisetin.
  • Benefits: Fisetin is also shown to encourage healthy sirtuin function in the body. Sirtuin proteins are the proteins that support optimal cell functioning.
  • Safety and Purity: This product is sourced using only the finest and purest raw ingredients. This is a non-GMO, vegetarian and gluten-free supplement, manufactured in the USA.

Pros:

  • Life Extension Bio-Fisetin capsules are 25 times more bioavailable than the other products.
  • Boosts longevity
  • Supports heart, eye, and kidney health
  • Inflammation management

Cons:

  • Doesn’t specify the dosage of fisetin per capsules

8. Natgrown Quercetin with Bromelain Supplement

Features:

  • Ingredients: This product combines 500mg of Quercetin with 200mg of Bromelain complex.
  • Benefit: This powerful blend of quercetin and bromelain supports the immune system and promotes healthy respiratory function.
  • Function: Quercetin naturally scavenges free radicals in the body, supporting healthy seasonal immunity. Quercetin also inhibits oxidation of LDL cholesterol and protects the cardiovascular system as well as the gastrointestinal tract. Bromelain, whereas being a protein digesting enzyme derived from pineapple stem, supports overall healthy immune system function.
  • Safety and Purity: The product is made of the highest quality ingredients in the USA. It is also free from soy, gluten, peanuts, wheat, tree nuts, and milk.

Pros:

  • Plant based ingredients
  • Supports balanced immune system
  • Promotes normal respiratory function
  • Supports healthy seasonal immune function

9. Toniiq Ultra High Purity Quercetin Capsules

Features:

  • Ingredients: Contains pure 95% quercetin. The product offers 1000mg of quercetin per serving, with one capsule containing 500mg of the highest-grade quercetin. Also, the quercetin is ethically grown, sourced and cultivated to maintain the high purity standards.
  • Function: Quercetin is a major bioflavonoid that has been researched and proven to have anti-allergy and anti-inflammatory effects. This product offers 95% pure quercetin which increases efficiency and potency.
  • Safety and Purity: This product is GMP-certified and made in an NSF-approved facility in the USA.
  • Quality: Toniiq Quercetin capsules are third party tested to ensure purity and the highest level of quality. They also test each batch themselves for any possible contaminants, impurities, or additives.

Pros:

  • Highly bioavailable
  • Highly purified
  • Highly potent
  • Quercetin has antioxidant and anti-inflammatory effects
  • Quercetin helps prevent heart diseases

Cons:

  • Strong smell
  • Might cause side effects for some people

10. Tru Niagen Nad+ Booster Supplement

Features:

  • Ingredients: Contains Niagen, which is a patented form of Nicotinamide riboside (NR), a unique form of vitamin B3 that is hard to find in nature. This product is a flagship super-nutrient with the power to increase NAD+ (nicotinamide adenine dinucleotide) levels in the body.
  • Function: NAD+ is essential for life as it is vital for the optimal functioning of the cells in our body. This patented form of NR (Nicotinamide riboside) is a powerful NAD+ booster present out there. This supplement works as a full-body supernutrient and supports the body’s many vital systems and functions as we age. It is clinically proven to elevate the levels of NAD+ in the body by up to 40-50% in around 8 weeks.
  • Scientific Affiliation: With more than 40 registered ongoing human studies and several published clinical trials, Tru Niagen is proven to raise NAD+ levels in the body.

Pros:

  • Supports healthy aging
  • Supports brain health
  • Supports heart healthy
  • Supports cellular defense and repair
  • Supports muscle health
  • Increases cellular energy
  • Suppresses daily lifestyle stressors 

Cons:

  • Might cause side effects

How to Choose the Most Effective Senolytic Supplements?

Before you start consuming any dietary supplement, it is very important that you do thorough research so that you don’t regret anything later.

Understanding your body’s needs, searching for the active ingredients of the product, its quality, purity, or possible side effects, is all very important to look for. Making a well-informed decision is the only way you can make the most of any senolytic supplement in your journey to a healthy life.

A few important factors to look forward to are:

Brand’s worth

As a thumb rule, never jump on a product from a brand that doesn’t meet your expectations. Reliability is a very important factor when it comes to any life extending supplements. Choose a renowned brand that has years of experience and a good reputation amongst its existing customers.

Descriptions

Always read the product description to get a better understanding of the product. Look for ingredients that you might be allergic to and avoid products that contain anything fishy.

woman reading the labels of medicine bottles

By going through the description, you will also get to know about the purity and quality of the product and other crucial factors such as whether you are eligible to take it (in case you fall into a special category). Thus, it is important to never skip the description.

Customer Feedback

Customer feedback is the biggest testimony of a product’s efficiency and quality. Keep in mind that no product can have a 100% happy customer base. If so, then there is a possibility that it is fake. A product cannot work for everyone out there, thus a few negative reviews make sense. But if a product works for the majority of customers, then it is proof that it is effective and of good quality.

Reliability

The reliability of the manufacturing brand is another imperative factor while choosing a senolytic supplement. Customer FAQs and ratings are crucial for determining this reliability factor. A reliable brand will always make sure to address all customer queries regarding the product.

What Are the Benefits of These Senolytic Supplements?

As we discussed earlier in the blog, senolytic compounds actively target senescent cells that are the main cause of age-related issues. Taking a senolytic supplement may help you clear out these senescent cells, allowing the healthy cells of the body to flourish. This can further lead to cellular longevity, in-turn supporting the body to effectively fight against age-related malignancies and diseases.

Senolytic drugs such as Dasatinib, Fisetin, Navitoclax, and Quercetin are observed to prevent cellular level damage caused by senescent cells, the root cause of aging.

What Is the Most Affordable Senolytic Supplement?

The cost of senolytic supplements varies widely depending upon the anti-aging ingredients used to formulate the product as well as the brand.

There are brands that sell a combination of quercetin and fisetin. Also, there are brands that sell any one of these or other senolytic compounds in pure form. You need to first narrow down your research depending on what your body needs. After that, only then can you do a price comparison of other similar products to find the most affordable option.

Who Can Take Senolytic Supplements?

Senolytic supplements, as we know, are effective in eliminating senescent cells, which are the aging cells in our body. Thus, it is not for anyone under 40.

Anyone above 40 can take senolytic supplements as a long-term health supplement to eliminate senescent cells and have healthy cell rejuvenation. It can also be taken as a course of treatment to fight any age-related ailment.

white pills on a woman's hand

If you are already on any special medication, then it is often advised to consult a healthcare practitioner beforehand. Also, pregnant women and breastfeeding mothers are not recommended to consume senolytic supplements.

What Supplements Are Senolytic?

Any supplement containing natural compounds such as fisetin, quercetin, curcumin analog, dasatinib, navitoclax, and piperlongumine, which are clinically proven to have senolytic activities, is senolytic in nature.

What Is the Most Effective Senolytic?

Studies show that fisetin is the most potent natural senolytic agent known to effectively destroy senescent cells by far. Fisetin is a bioactive flavonoid that is found in fruits such as strawberries, grapes, and apples.

Several studies have proved the effectiveness of fisetin in fighting numerous age-related diseases. Fisetin is also reported to have anti-inflammatory, anticarcinogenic, and neurotrophic properties. 

Are Senolytic Supplements Effective?

Many studies show promising results of senolytic agents being effective in eliminating senescent cells and fighting age-related illnesses. However, senolytic agents are still in the research and development phase as far as humans are concerned. Thus, one should take senolytic supplements after consulting their health care provider, just to be safe.

Is Resveratrol a Senolytic?

No, there is no reported senolytic activity of resveratrol.

Conclusion

We hope we have helped you understand “what are senolytics” and how they counter senescent cells to prevent or treat age-related conditions. Now the decision is all yours! If you want to include senolytic supplements in your daily routine to fight aging or promote healthy living, then you have all the information you require.

We have also enlisted the ten best senolytic supplements based on customer reviews and other crucial factors.

Pick the one that best suits your body’s needs and make the most of this path-breaking research that has brought us a step closer to our age-old quest for a longer and healthier life.

You can also check the Infinity NAD+ Longevity product that can help you reverse the aging process.

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