Saccharomyces Boulardii for Leaky Gut: Is It Effective?

 by Dr. Steve Hruby, D.C.
Reviewed by Dr. Steve Hruby, D.C.

SuperHumans are the toughest, fittest, healthiest and happiest human beings on this planet. My mission is to help you realize your superhuman potential and learn how to live a long, happy and healthy life.

  Fact Checked
 by Rhealyn Tropia, RMT
Reviewed by Rhealyn Tropia, RMT

I’m a content organizer, fact-checker and super mom who ensures content is medically-reviewed, highly accurate, and engaging. My passion is organizing information and ensuring the facts are presented in a manner that is interesting and easy to understand.

saccharomyces boulardii for leaky gut

The human gut is the largest and most complex ecosystem in the body, comprising trillions of microorganisms. Unfortunately, a diet rich in processed foods and sugars can damage this sensitive system.

If you’ve never had to deal with leaky gut syndrome before, you might not know how it differs from other disorders. Here’s what you need to know about gut issues, and how to use Saccharomyces Boulardii for leaky gut.

If there’s one thing we can probably all agree on, it’s that your gut is the hub of your health. It’s home to the microbiome (the term for all the bacteria that reside in your body) and acts as the gatekeeper between food, drink, and the outside world. When it comes to digestion, it seems there are no shortcuts.

What Is Saccharomyces boulardii?

Saccharomyces boulardii is a type of yeast that’s found in the digestive tract. It’s also sometimes called Sporolactobacillus boulardii, which is the same thing but with a longer name.

It’s often used as a probiotic to treat diarrhea and prevent antibiotic-associated diarrhea. It’s also used to treat Crohn’s disease, irritable bowel syndrome, and other gastrointestinal disorders.

Is saccharomyces boulardii a probiotic? Because it’s a type of yeast, saccharomyces boulardii isn’t technically considered a probiotic. Instead, it’s an “immunomodulator,” which means that it helps boost your immune system.

What Is Saccharomyces boulardii good for?

The reason for its popularity is that S. boulardii is able to survive your stomach acid and make it through your small intestine into your large intestine—which is where most probiotics stop working because of the high acidity there.

In fact, S. boulardii has been shown to be effective at treating antibiotic-associated diarrhea (AAD), traveler’s diarrhea (TD), inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), Crohn’s disease, ulcerative colitis, and Clostridium difficile infections (CDIs).

Some other Saccharomyces boulardii benefits include:

  • Reducing bloating and constipation
  • Keeping your immune system strong
  • Promoting healthy digestion by encouraging the growth of good bacteria in your gut

How S. boulardii Can Help With Leaky Gut

The most common way that Saccharomyces boulardii helps with leaky gut is by reducing the inflammation in your digestive tract. This inflammation is caused by a number of different factors, including food allergies and sensitivities such as gluten intolerance, bacterial infections, parasites, and even stress.

constipated woman

But when you take S. Boulardii on a daily basis, it helps to reduce this inflammation in your body so that your digestive system can begin to heal itself.

Additionally, it helps restore the good bacteria levels in your digestive tract to normal levels. Many people who suffer from leaky gut have had their good bacteria killed off or damaged by certain types of antibiotics or other medications they’ve taken over time.

These medications can also kill off good intestinal flora which helps keep bad bacteria under control so they don’t overgrow into an infection like Candida Albicans or Clostridium Difficile (C-diff). When this happens, these infections can cause serious illnesses like diarrhea or even death if left untreated.

What Sets S. boulardii Apart From Other Probiotics?

This probiotic has some unique properties that set it apart from other probiotics:

  • It helps restore the normal balance of good bacteria in the gut by competing with harmful bacteria for space and nutrients. The good bacteria crowd out the bad ones, making it harder for them to multiply and cause health issues like leaky gut syndrome or IBS symptoms.
  • It can survive stomach acidity better than most other strains of probiotics. This means that you don’t have to take as many capsules or worry about it losing its potency before reaching your digestive tract where it can do its job.
  • It helps reduce inflammation in your body by helping regulate your immune system response when you’re exposed to harmful pathogens like viruses or parasites.

Research on S. Boulardii’s Effects on Leaky Gut

Study #1

In one study published by the National Library of Medicine, Saccharomyces boulardii CNCM I-745, which has already been used in the treatment and prevention of diarrhea of various etiologies (associated with antibacterial drugs or infectious diseases), has been shown to protect the barrier function in a variety of diseases.

Study #2

In another study, S. boulardii CNCM I-745 activates the MAP kinase pathway and impacts the pathway to signaling PI3 kinase. This means that S. boulardii CNCM I-745 emits enzymes that aid in the delivery of nutrients to both the yeast and the host organism. The growing presence of digestive enzymes clearly contributes significantly to S. boulardii CNCM I-745’s clinical effect.


Study #3

Another study discusses further how Saccharomyces boulardii reserves the barrier function within the gut. In order to protect your body from the harmful effects of toxins and other harmful substances in your diet, your digestive system has a powerful barrier that keeps them out of your bloodstream.

The cells that make up this barrier are called tight junctions. When they’re healthy and functioning well, they form a tight seal between the cells that line your intestines.

When they become damaged or inflamed by chronic stress, autoimmune disorders, or infections like H. pylori (bacterial infection of the stomach), they begin to lose their ability to create this seal and allow partially digested food particles through into your bloodstream where they can cause inflammation and damage other parts of your body such as joints or brain tissue.

How Much S. boulardii Should I Take?

When taking probiotics for a leaky gut, it’s important to keep both frequency and quantity of intake in mind. The amount of S. boulardii you take will depend on your condition and the severity of your leaky gut symptoms.

Most people start with a dosage of one to two capsules per day, but it may be necessary to increase the dosage as your symptoms improve. You should be able to see results within two weeks, though some people experience relief within days.

Risk and Side Effects of S. boulardii

Saccharomyces boulardii is a probiotic that’s used to help treat and prevent diarrhea, as well as improve the health of the digestive system. It can also be used to treat or prevent yeast infections and help maintain proper levels of good bacteria in your gut.


As with any supplement, there are some risks and side effects associated with using S. boulardii. These include:

  • Gas
  • Nausea
  • Bloating
  • Headache

It’s best to always consult with your doctor before taking any probiotics.

Can Saccharomyces boulardii Cause Diarrhea?

Saccharomyces boulardii is a probiotic yeast that has been shown to help with leaky gut and other digestive issues. However, it’s important to note that it can cause diarrhea in some people.

If you’re taking Saccharomyces boulardii and experience diarrhea, you should check with your doctor to see if you have an infection or other underlying condition that’s causing this problem.

If your doctor confirms that the diarrhea isn’t due to another condition or infection, then you may need to discontinue the use of this product until you have consulted with your doctor about what actions should be taken next.

What Probiotic Is Good for Leaky Gut?

There are so many good leaky gut probiotics available in the market, but how do you determine which one is best for you?

The first thing to consider is what kind of probiotic will work best for you and your specific situation.

For example, if you have an autoimmune disease such as Crohn’s disease or ulcerative colitis, then it’s important that you choose a probiotic that has been clinically proven to help with inflammation and chronic diarrhea. Products like Optima ensure that you have a power-packed serving with each scoop.

Another important factor to consider is how many strains of bacteria are included in each capsule or tablet. Some products contain only one strain of bacteria while others contain up to three different strains per capsule or tablet.

You’ll want to make sure that whatever product you choose has at least three different strains of bacteria since this will ensure that your body gets all of the nutrients it needs from probiotics as quickly as possible.

Does Saccharomyces boulardii  Reduce Inflammation?

Saccharomyces boulardii is a type of yeast that is used as a probiotic. It has been shown to reduce inflammation and help treat the leaky gut syndrome.

woman in bed with both hands placed on her stomach

This can help reduce symptoms like bloating, gas, and abdominal discomfort. Many people use Saccharomyces boulardii for the leaky gut because it has been shown in studies to reduce inflammation in the digestive tract.

How Long Does It Take for Saccharomyces boulardii to Work?

How quickly do probiotics begin to work, such as Saccharomyces boulardii? The effects of Saccharomyces boulardii can be felt very quickly, but the full benefits will not be realized until a few weeks after you begin taking it.

The reason for this is that when you take a probiotic supplement, it takes some time for the bacteria to populate your intestinal tract. The length of time it takes will vary depending on how healthy your digestive system is at the time you begin using it.

In addition, it’s important to note that certain factors can affect how quickly an individual responds to a particular strain of probiotics. For example, if you’re taking other medications or have other health conditions that require additional treatment, this may slow down the effectiveness of your treatment plan.

When it comes to the optimum time to take probiotics, there are a few things we can look at:

  • What does the research suggest? Some studies have shown that taking probiotics before bedtime or on an empty stomach may be more effective than at other times. However, these studies were small and not conclusive. More research is needed.
  • What does your gut feel like? If you’re feeling bloated and gassy, then it might be a good idea to try taking probiotics at different times of the day until you find one that works best for you. This will also help you figure out which bacteria strains work best for your body type and conditions.


Overall, S. Boulardii can be a useful tool in the management of digestive and intestinal health. It bundles several benefits into a single program that’s readily available over the counter, without needing a prescription from your doctor. 

However, it does require ongoing administration to maintain its effectiveness – so consider using it for two months straight or longer if you haven’t achieved your desired results.

Keep checking in for more articles on overall wellness, health, and longevity. With the right information resource, a balanced lifestyle, and the most potent tools and supplements, we can all be SUPERHUMN!

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