Can You Take Melatonin and Adderall?

 by Dr. Steve Hruby, D.C.
Reviewed by Dr. Steve Hruby, D.C.

SuperHumans are the toughest, fittest, healthiest and happiest human beings on this planet. My mission is to help you realize your superhuman potential and learn how to live a long, happy and healthy life.

  Fact Checked
 by Rhealyn Tropia, RMT
Reviewed by Rhealyn Tropia, RMT

I’m a content organizer, fact-checker and super mom who ensures content is medically-reviewed, highly accurate, and engaging. My passion is organizing information and ensuring the facts are presented in a manner that is interesting and easy to understand.

melatonin and adderall

Sleeping with Adderall isn’t easy. This medication is used to treat neurological symptoms such as attention span, energy, and focus. Adderall has a multitude of effects on the person taking the medication. You may have better focus if you take it regularly, but that isn’t a permanent solution.

Today we’re discussing the functioning of Adderall and its potential side effects. Melatonin and Adderall both help in managing insomnia and sleeping disorders in adults. Children with ADHD (Attention Deficit Hyperactivity Disorder) who have difficulty sleeping are prescribed melatonin.

Let us see why doctors recommend this medication for better sleep and why it’s a healthy supplement.

How Does Adderall Function?

Adderall is a medication designed to treat ADHD, ADD, or narcolepsy. It’s a prescription drug that has a combination of dextroamphetamine and amphetamine. Adderall works on our central nervous system. It helps in balancing the natural chemicals of the brain and improves concentration.

Adderall helps the brain release dopamine and prevents monoamine oxidase, resulting in better focus and alertness. Although Adderall is a regular medication for the management of mental disorders, it’s seen as a performance enhancer in healthy people.

Adderall improves attention and focus, but it may also impact the body, changing its sleeping patterns. Almost 33% of people experienced sleep disturbances, insomnia, fatigue, and frequent awakenings.

Some Adderall users may also experience a decrease in REM sleep. For people with ADHD, melatonin may be the best sleep aid to take with Adderall.

When Should You Take Melatonin?

Melatonin is a hormone produced by the brain when it’s dark. It’s essential for a healthy sleep cycle. It assists the brain when it’s time to sleep. An ADHD brain has a delayed melatonin response.

Research shows that melatonin onset for most adults is 9.30 pm, but with ADHD, it’s an hour delayed. The same case is with ADHD children—it’s around 10.15 pm. This sleep delay is due to late melatonin onset in both adults and children with ADHD. Healthy people may fall asleep within two hours of the onset of melatonin, but ADHD individuals may take three hours to fall asleep.

Melatonin’s delayed onset helps in explaining why people with ADHD sleep late and experience sleeping issues. Research shows that 25 to 30 percent of people with ADHD have sleep disorders. Therefore, it’s suggested to take melatonin as a supplement to treat ADHD disorder in adults and kids under the supervision of medical practitioners. It may help in improving sleep quality.

The best time to take Melatonin is 90 to 120 minutes before bedtime. It allows the body to metabolize melatonin and signals the brain that it’s time to go to sleep. Melatonin shouldn’t be regarded as a permanent sleep aid, though.

Melatonin doesn’t work immediately before bed, since melatonin takes at least two hours to take effect. What works here is the placebo effect, where the thought of sleeping relaxes your mind and works as a sleep tonic. It makes a person calm, and they go to sleep.

Can You Take Melatonin and Adderall Together?

Adderall is a CNS stimulant used for narcolepsy and ADHD. But melatonin comes under the drug class of sedatives and hypnotics, and nutraceutical products used to treat insomnia and jet lag.

bottle melatonin tablets and sleeping mask

Melatonin and Adderall together are shown to have positive impacts on patients with sleeping disorders.

Nearly 50% of people experiences sleep issues if they have ADD. Sometimes, Adderall may worsen the problems. Here, melatonin can be the solution for many.

Melatonin is a safe and effective stimulant to manage sleep. It’s an over-the-counter medicine sold in many regions that is a synthetic form of a hormone that aids better sleep. Sometimes, healthy people suffer from sleep issues due to stress or work pressure. For them, adaptogens for sleep are a better solution.

Taking Melatonin and Adderall at the same time hasn’t been shown to have any interactions. However, that doesn’t mean no interactions exist. Talk to your healthcare provider before you take these medicines.

Furthermore, melatonin’s long-term use hasn’t been thoroughly studied. There may be a few areas where the use of melatonin may have adverse effects. This time, the doctor may prescribe a good hygiene strategy for quality sleep.

Can You Take Adderall and Sleep Aids Together?

If you’re struggling with insomnia even after taking Adderall, your doctor will conduct some tests and tell you how to improve the quality of your sleep.

He may ask you to keep a sleep journal to learn about your sleep pattern. For example, people suffer from frequent sleep interruptions at night, or they may fall asleep late.

It’s important to know how Adderall impacts your sleeping patterns, as this will guide you through the treatment plan. In many cases, it may take some time, and medications alone may not solve the issue, as the interactions of Adderall with other substances may be reasonably high.

In the absence of melatonin, your doctor may prescribe L-theanine instead. It’s comparatively safe and is tolerable for people with ADD.

Whatever the case is with Adderall, don’t experiment with sleeping medications on your own. Interactions of a few medicines can be dangerous and have severe health impacts.

Speak to your doctor to ensure safe treatment and know the potential side effects of Adderall may include:

  • Headaches or migraines
  • Anxiety or panic attacks
  • Constipation and abdominal pain

How Can I Get Adderall To Wear Off Faster So I Can Sleep?

The most frequent question asked by most patients is how to make Adderall wear off so I can sleep. This is because many people experience sleeping problems after the medicine and want it to wear off. Unfortunately, you can’t wear off medications.

Adderall causes side effects like dizziness, dry mouth, and nervousness. Insomnia is the worst side effect of Adderall. It may also cause emotional problems like stress, anxiety, and irritation.

If you talk to your medical professional, he will tell you how to eliminate the symptoms of Adderall by reducing the dosage. When you lower the dose, it causes fewer issues.

person lying on bed with hands covering eyes

For optimal sleep, your doctor may ask you to take medicine in the morning rather than at night. This way, it won’t mess with your system.

Melatonin is a safe option, but many medical professionals may advise other strategies for improving sleeping habits rather than taking medications. Your doctor may ask you to take the best prebiotic for sleep or lower the Adderall dose to check the effects. He might also tell you to practice good sleep hygiene habits like:

Maintaining Routine

Create a time-based routine that could aid in enhancing your body’s innate rhythm. You have to have a set bedtime and wake-up time. It will gradually encourage your brain to fall asleep at a particular moment.


You may try relaxation techniques like a warm shower, yoga, or diffusing essential oils. While following these natural techniques, you can relax the body, calm the mind, and make yourself sleep naturally.


Dark, cool, and quiet rooms help you sleep better. Avoid watching mobile phones while going to bed and listen to relaxing music to be comfortable.


Melatonin and caffeine interaction before going to bed acts adversely. The doctor may ask you not to take caffeinated drinks at night if you’re habitual. Also, it’s said to avoid eating late at night.


Regular exercise improves health in multiple ways, including quality sleep. If you exercise regularly, it may offset the side effects of Adderall. You can also take herbal teas to calm your mind and body. Just make sure that it doesn’t interact with your medications.

Why Does Taking Adderall Help Me Sleep Better?

High levels of focus may cause sleep issues in many people. However, some people may respond in another way. Amphetamine in Adderall may make people active, but people with ADHD may have calming and sleep-inducing effects.

Clinical trials have shown that 6% of people felt fatigued after taking Adderall. You may also have significant effects if you stop Adderall, especially if you have been taking this medicine for some time.

If Adderall makes you exhausted, talk to your doctor. He’ll tell you the root cause and ways to get rid of it.

Tips for Getting a Better Night’s Rest While Taking Adderall

Use the Lowest Effective Dose by Gradually Scaling Up

The dose of Adderall should be started at the lowest possible level and gradually increased over time. Avoid taking too much dosage—it causes insomnia.

The optimal dosage of medicine is provided by your healthcare professional. Don’t exceed the limit. Some patients may take weeks to months to adjust to the dosage.

white round tablets on a blue background

But that doesn’t mean that it doesn’t benefit you. Patients benefit from the medicine from the beginning of medicine usage within 30 minutes of medicine consumption. Unfortunately, this is why people start consuming higher dosages for maximum benefits in a shorter time frame. This is when the problem begins. People have sleeping disorders, insomnia, or face paced- titration.

Hence, always be in touch with your doctor if you face any health issues.

Avoid Drug Interactions That Make Insomnia Worse

Adderall has significant clinical interactions with many medications that cause insomnia and dizziness. Hence, avoid mixing these medicines with Adderall.

These drugs include duloxetine, escitalopram, fluoxetine, sertraline, tramadol, levothyroxine, and omeprazole. These are a few medicines, but many others may also react with Adderall. Thus, talk to your doctor if you’re on certain medications, and he will prescribe you medications accordingly.

Manage Sleep Issues Resulting From Adderall and ADHD

Some people with ADHD might face significant sleep disturbances with Adderall that may require a doctor’s advice.

Studies show that 19.3% of children with ADHD have sleep issues at least once a week. And almost 50-60% of adults with ADHD have sleep disorders. It includes sleep latency, less sleep duration, daytime sleeping for long hours, frequent awakenings, and specific issues like leg syndrome, periodic leg movement disorder, and sleep disorder breathing.

On the contrary, many people with ADHD report that Adderall makes them sleepy. Let the doctor decide what’s best for you.

Manage Adderall’s Non-sleep Related Side Effects

Adderall also has indirect effects on sleep. It includes symptoms of anxiety, headache, abdominal pain, diarrhea, or constipation. It’s not that everyone experiences these issues, but some people may have indirect effects on sleep.

Use Adderall as Prescribed by Your Physician.

Adderall is available in many countries by doctor’s prescription. In many countries, drug regulation is laxer. It’s recommended to strictly use it on a doctor’s prescription. Adderall can also be scary if you miss a dose—the symptoms might reverse with hallucinations, illusions, insomnia, anxiety, confusion, and mood swings. Furthermore, it may also hamper your social and professional life.

Establish a Relaxing Bedroom Atmosphere.

ADHD is a chronic condition that begins in childhood and lasts until adulthood. The affected person may be unable to sit in a place, lack patience, or have a poor attention span with excessive movements.

Always set up a comfortable bed and bedroom environment for better sleep. You can choose calming colors, props, and furnishings.

You can also check does chocolate cause weird dreams.

How Long After Taking Adderall Can I Take Sleeping Pills?

The doctor might prescribe you a low dosage of antidepressants. He may give you medications to promote sleep—Valium or Xanax. There are no interactions between sleeping pills and Adderall, but always keep a gap of two hours between the two.

woman in pajamas drinking from a glass

While Adderall enhances focus, sleeping pills relax the mind for sleep. So, keep in mind to maintain a gap between the two. Also, you may ask your doctor if he allows you to take Adderall in the morning instead of at night. Then you will have no issues.

All Your FAQS Related To Adderall and Melatonin Interaction

Can You Take Melatonin With ADHD Meds?

Yes, it’s safe to take melatonin with ADHD medicines. The short-term use of melatonin supplements appears safe for inducing sleep. A study found that children with ADHD who took melatonin daily with their ADHD medications fell asleep faster and slept longer. As per the doctors, it’s safe.

But according to NCCIH, the long-term safety of supplements is lacking. There isn’t much information about heavy dosage and possible side effects. Therefore, parents and adults with ADHD should consult a physician before starting any medications.

What Can Help You Sleep on Adderall?

Some people sleep better with Adderall, and some may have insomnia. A doctor may prescribe temporary medications to navigate the Adderall crash. It includes sleeping medicines like Valium or Xanax. A doctor may also prescribe you a low dose of antidepressants. Some doctors may ask you to follow a bedtime routine and maintain good hygiene.

Can I Take Sleep Medication With Adderall?

If you have sleeping disorders while on Adderall, your doctor will conduct a few tests to determine the root cause and evaluate your condition.

Maintaining a sleep journal may be recommended if you’re experiencing frequent wake-ups at night. He’ll prescribe you sleep medications if necessary. Don’t take it without a physician’s advice, as interactions between Adderall and many medicines are reasonably high. It may be dangerous and may worsen your situation.

What Should You Not Mix Adderall With?

As antacids absorb quickly, they shouldn’t be taken with Adderall. It’s also advised not to take MAO inhibitors such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine.

These are a few that we have mentioned, but there are many more medicines you should avoid with Adderall. Thus, you should always ask your doctor if you’re already on certain medications.


Sleep disturbances are a common issue among patients on Adderall. In this article, we have provided some possible ways to manage and treat insomnia that can be caused by taking Adderall. Maintaining a healthy routine with proper diet and daily exercise is recommended by doctors.

Patients on Adderall often get mood swings and a lack of energy and focus. For that, you can try our product Serenity which can help with better rest and sleep.

Don’t exceed the drug dosage and avoid taking medicines and food items that may interact with Adderall. ADHD patients should focus more on better sleep by focusing on sleep hygiene and medical adjustments.

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