7 Best Leaky Gut Supplements For Healing Leaky Gut [2022]

 by Dr. Steve Hruby, D.C.
Reviewed by Dr. Steve Hruby, D.C.

SuperHumans are the toughest, fittest, healthiest and happiest human beings on this planet. My mission is to help you realize your superhuman potential and learn how to live a long, happy and healthy life.

  Fact Checked
 by Rhealyn Tropia, RMT
Reviewed by Rhealyn Tropia, RMT

I’m a content organizer, fact-checker and super mom who ensures content is medically-reviewed, highly accurate, and engaging. My passion is organizing information and ensuring the facts are presented in a manner that is interesting and easy to understand.

best leaky gut supplements

Before we dive right into the best leaky gut supplements for 2022, let me start first with a small biochemistry lesson: One of the primary functions of the gut is to absorb the benefits from food and turn it into fuel that can provide us with the energy we need for everyday activity.

It literally processes our food for us, leaving very little for our body to actually digest because most nutrients are already carrier into your blood stream immediately after consumption.

So no matter where you are on your quest to improve your leaky gut, I’m here to help you get right to it. In this article, we’ll explore some of the best supplements out there, and discuss why they work so well, as well as which ones might not be right for you.

7 Science-Based Supplements For Healing Leaky Gut

A leaky gut occurs when the intestinal lining is damaged or becomes too porous, allowing larger food particles to get through. When this occurs, food can pass into the bloodstream and trigger an immune response in the body. This results in inflammation throughout your body and can lead to many health problems such as autoimmune disease, food sensitivities and skin conditions like eczema.

There are many symptoms associated with a leaky gut including: brain fog, fatigue, inflammation (acne), bloating, gas and digestive issues like constipation or diarrhea.

The severity of these symptoms will depend on the extent of damage done to your intestinal lining which may be caused by foods you eat on a regular basis or something more serious like an autoimmune disorder like Crohn’s disease or ulcerative colitis for example.

What are the best supplements for healing leaky gut? Backed by science, here are 7 of the best when it comes to helping maintain your gut health at optimal levels.


It is an amino acid that is found in high concentrations in the small intestine and promotes the production of collagen and other proteins. L-glutamine can be taken as a powder or capsule, but it’s very important that you only buy it from reputable manufacturers and never from any site offering free samples.

Glutamine can be used by anyone with leaky gut, including those with Crohn’s disease, irritable bowel syndrome (IBS), ulcerative colitis, celiac disease, or any other inflammatory condition.

Vitamin D

Vitamin D is a fat-soluble vitamin which aids in regulating levels of phosphorus and calcium in the body. It also plays an important role in immune function, muscle function, and bone growth.

This vitamin protects your body from the harmful effects of stress, which is a major factor in causing leaky gut. Studies have shown that vitamin D deficiency can lead to inflammation and autoimmune disorders. Vitamin D also reduces inflammation in your body, and this helps with leaky gut as well.


Probiotics are live bacteria that help your body with digestion, absorption and immunity. These bacteria can be found in fermented foods such as yogurt and sauerkraut. There are many types of probiotics available in the market, but some are more effective than others.

a bowl of kimchi

Kefir is one of the most popular probiotic drinks and contains both Lactobacillus and Bifidobacterium species. This type of probiotic has been shown to improve intestinal permeability in patients with Crohn’s disease by increasing tight junction proteins.

Digestive Enzymes

Digestive enzymes are a unique blend of enzymes that helps to break down your food and digest it, which is why it’s so effective for people with a leaky gut.

There are many different types of enzymes, including lipase, protease, amylase, cellulase, lactase, and more. These enzymes are designed to help you digest all types of foods and keep them moving through your digestive tract quickly and easily.

It also contains probiotics to support healthy bacteria in the gut as well as prebiotics to feed those good bacteria.

The combination of these two ingredients helps keep your digestive system running smoothly and healthy throughout the day so you don’t have any trouble absorbing nutrients from your food or experiencing gas or bloating after eating meals high in fat or fiber like beans or whole grains.


Fiber can be found in foods like nuts and seeds, fruits, vegetables, grains and legumes. Fiber helps to remove toxins from your body and also helps you feel full for longer periods of time which can help with weight loss.

In addition to this, fiber also helps to strengthen your immune system by improving nutrient absorption from food into your bloodstream.


Zinc aids in the production of collagen, which helps to repair and seal the intestinal tract. It also helps to regulate your immune system, which can be a struggle for those with leaky gut syndrome. Zinc has been shown to reduce intestinal permeability, which is exactly what you want if you have leaky gut.

One thing to keep in mind is that zinc deficiency can cause poor absorption of nutrients, so taking a zinc supplement alone may not be enough. You need to make sure you’re getting enough nutrients in your diet as well.         

Collagen Powder

Collagen is a protein that is found in connective tissue, bones, and skin. It helps build the strength of your hair, nails and skin. Collagen powder is made from grass-fed, pasture raised cows and it is free from hormones and additives.

This product can be added to smoothies or any other foods that you like to eat. It also has no taste so you will not be able to notice a difference in what you are eating. This supplement can be taken by anyone who has leaky gut because it helps reduce inflammation in the body and helps build strong bones and joints.

It also helps with weight loss by building muscle mass instead of fat cells which can lead to an increase in metabolism as well as reducing cravings for junk foods such as sugar or carbs which means less calories consumed per day.

Top 7 Leaky Gut Supplements of 2022 – Reviews

With a growing number of people becoming affected by leaky gut syndrome, scientists are working hard to understand and find a cure for this devastating disease that can completely change your life if left untreated.

If you or someone you know is suffering from leaky gut, I hope you find these leaky gut supplements reviews helpful. Let’s do a leaky gut cure review on the best leaky gut supplements 2022:

Leaky Gut Revive


  • Helps improve digestion and overall health of your body
  • Also very effective for appetite suppression if taken before meals
  • High quality of the powder
  • Very easy to mix into your food or favorite beverage


  • A bit pricey compared to other supplements
  • The declared volume on the container might not be exact as when you use the product. Pay attention when using the scoop and measuring.
  • First time users might experience nausea and bloating, make sure to observe the effects on your body in the first few days

Terra Origin


  • Helps with indigestion, gas, bloating, & tummy discomfort.
  • Helps you get your diet back on track
  • This comes in a wide array of flavors, including a vegan variant
  • The flavoring tastes good
  • Product dissolves easily in water or other beverages


  • Make sure to observe the product’s effect on your body for the first few days, as you might feel bloated or constipated
  • You might also experience cramps if consuming the product for the first time

Vital Proteins


  • Proteins are an essential part of stomach lining repair supplements, which is one of the core ingredients of Vital Proteins
  • Has collagen which promotes healthy hair and skin, and helps in gut repair
  • Helps you get a good night’s sleep as it contains glycine in its mix


  • It has a taste which you might need to get used to or dull by adding more flavor to your drinks
  • This formula does not dissolve too well when mixed into cold liquids
  • It has an added synthetic Vitamin C GMO
  • Best to observe skin reactions to the product, in case of breakouts in your face or skin, discontinue use

Align Gut


  • A very quick way to get your required daily dose of gut supplement
  • This supplement comes in pill form and is very easy to ingest
  • It has no aftertaste
  • Helps to get your gut health and ultimately your immune system back on track


  • Double the price as compared to other leaky gut supplements
  • You might experience gut purging for the first few days or during the first week, if these symptoms persist, discontinue taking and consult a medical professional

L Glutamine Powder


  • There are several leaky gut powder supplements available in the market, and L-Glutamine makes it to this list, in its pure form it is digested directly by the gut.
  • Easily relieves so many gut health issues such IBS, bloating, and many more
  • Promotes regular bowel movement
  • This product dissolves easily and has a very mild flavor, making it ideal to mix into your favorite food or beverages


  • Ease up on the quantity of consumption, especially if it’s your first time using this product.
  • You might experience hot flashes, feeling nauseous, palpitations, and anxiety. Cut on the servings if you experience this. In case the symptoms continue, stop taking the product and consult your doctor immediately.

Doctor’s Best


  • Helps you deal with several serious gastrointestinal problems such as malabsorption and maldigestion
  • Contains a wide spectrum profile of powerful enzymes
  • This product is also a great solution for anyone suffering acid reflux, GERD IBS, heartburn, and many more gut issues
  • Highly potent formula
  • Comes in capsules which are convenient to take daily
  • This product is certified vegan


  • On the higher end when it comes to price compared to other supplements
  • The capsules could be hard to dissolve for some
  • It is not recommended to use this supplement if you are taking antibiotics or microbials as they could counteract the enzymes

Optima Healthy Gut Solution

What is the best supplement for leaky gut? I would highly recommend Optima Healthy Gut solution.

  • Optima has a cutting edge Gut Health Formula
  • This supplement contains all the digestive cleaning powerhouses including the best enzymes for leaky gut, combining them into one supplement to get your body going
  • It helps you get to a state of less fatigue, and more energy to expend
  • This also increases your stamina and improves your mood
  • Helps eliminate wastes and supports you in your weight loss goals
  • Improves your overall digestive health
  • Improves your gut’s ability to absorb nutrients
  • Reduces risks of inflammation in your body
  • Helps you heal or manage leaky gut syndrome


  • There are no known or recorded side effects or contraindications so far in using Optima

How Leaky Gut Supplements Such As Optima Healthy Gut Can Help You?

Now that you have gone through a list of the best supplements for leaky gut syndrome, let’s see how they can specifically help you with your healthy gut goals.

yellow tablets from a brown medicine  container
  • Support digestion. One of the benefits in taking leaky gut supplements such as Optima is that they support digestion.

In fact, one of the main reasons you have a leaky gut is because you have trouble digesting food. This means you’re eating more than your body needs, which means your body has to work harder to process it all. And this can lead to inflammation and oxidative stress in your body, which can eventually cause more problems than just a leaky gut.

So when you take a supplement like Optima, it helps you digest food better and make sure that your body doesn’t have to work as hard to get rid of waste products from those foods.

This will help reduce inflammation and oxidative stress—which means less risk of developing other diseases or conditions later on down the road.

  • Support the intestinal wall. The intestinal wall is a part of your digestive system that helps to keep harmful substances out of your body and maintain healthy levels of good bacteria. If this lining becomes damaged, it can allow substances that should not be in your body to pass through into other parts of your GI tract. This can cause problems such as bloating or abdominal pain.

Gut supplements help repair and restore the intestinal wall so that it is able to do its job effectively. This can help with many issues related to digestion, including constipation and diarrhea, cramps after eating and gas pains.

Leaky gut supplements promote healthy gut bacteria by supporting their growth and boosting their ability to fight off bad bacteria. This can improve your overall digestion, which can also help reduce bloating and other symptoms associated with a leaky gut.

That means that it can remove harmful chemicals from your system, which will give you more energy and help you to feel better overall. It also helps to improve your digestion, which will make it easier for you to absorb nutrients from the food that you eat.

Potential Side Effects Of Other Leaky Gut Supplements

While there are many benefits of taking a leaky gut supplement, there are some potential side effects that you should be aware of before purchasing.

  • Constipation. If you’re taking a leaky gut supplement, you might notice that your digestion is off. This could be due to constipation, which is one of the potential side effects of taking leaky gut supplements. The body has a natural balance that it tries to maintain, and when you take too many supplements or eat too much of a certain food, your body may react by slowing down digestion and eliminating waste more slowly. This can cause constipation.
  • Bloating. Bloating is one of the potential side effects of taking leaky gut supplements. This can occur when you’re taking too many supplements, or if you’re taking them with other medications or supplements. If you’re experiencing bloating after starting to take a leaky gut supplement, try reducing your dosage or switching to another supplement that’s better suited for your needs.
  • Diarrhea. It can be particularly uncomfortable and distressing, so it’s important to know what to do if you experience diarrhea while trying to heal your leaky gut.

Diarrhea is defined as having at least three loose or watery bowel movements per day for three days in a row. It can be caused by many different things, including food poisoning and viruses. But it can also be a symptom of a more serious condition like Crohn’s disease or ulcerative colitis.

If you have diarrhea that lasts longer than two weeks, see your doctor immediately because it could be a sign of something more serious than just the leaky gut supplements you are taking.

woman lying on the sofa holding her tummy
  • Headaches. While this is not common, it does happen. If you are unsure whether or not you have leaky gut syndrome and would like to avoid headaches while taking leaky gut supplements, talk with your doctor about how to manage the risk of headaches.
  • Exhaustion. In addition to the more common side effects of leaky gut supplements, such as diarrhea, bloating and gas, exhaustion is one of the potential side effects of taking these supplements.

In many cases, this is caused by an increase in stress levels. When you take a leaky gut supplement, your body will go into repair mode and begin to heal itself.

The first thing it does is work through any toxins or waste that might be lingering in your system. This can cause the sensation of being tired or exhausted because your body is working hard to get rid of all these toxins.

However, if you have not been eating properly or have been experiencing any other symptoms of digestive distress before taking a leaky gut supplement then this could be a sign that something else is wrong with your body besides just leaky gut syndrome.

It’s important to speak with your doctor before taking any supplements so that they can determine whether or not there is another issue going on that needs treatment first before trying these types of treatments for themselves.

Here are some more tips for dealing with leaky gut supplement side effects:

  • Make sure you’re taking the right amount. Take more than the recommended dose and you might experience headaches. But don’t take less than recommended either.
  • Take it with food if possible. This will help slow down absorption and reduce any possible side effects from taking too much too quickly.
  • Drink plenty of water throughout the day to stay hydrated—this helps your body process nutrients more efficiently so there’s less chance of buildup in your system.

Gutsy Answers to Frequently Asked Questions

What Supplements Help Repair Gut?

There are a number of supplements that can help repair the gut and restore its health.

One way to start is by taking L-glutamine, which is an amino acid that can help repair the lining of the intestines. It’s also found in certain meats, but it’s best to take it as a supplement so that you’re getting enough.

Another supplement that may help is fish oil, which contains omega-3 fatty acids. These fatty acids help prevent inflammation in the body and can aid in healing damaged tissue.

Finally, probiotics are one of the most important supplements for gut health because they are live bacteria that can help restore balance to your digestive system.

There are products out there that combine all of these into one formula, such as Optima, so that you get all the daily requirements you need for your gut health.

Which Probiotic Is Good for Leaky Gut?

For people with leaky gut, probiotics can help repair the lining of their digestive tract and also promote healthy bacterial balance.

yogurt and frozen berries

Probiotics are microorganisms that live in our guts and help us digest food, produce vitamins, and fight off harmful bacteria. They are found in fermented foods like yogurt and kefir and can also be taken as supplements.

Probiotics come in many different types, but two of the most common strains are Lactobacillus acidophilus and Bifidobacterium lactis. These two strains have been shown to help reduce symptoms of leaky gut by helping repair damaged tissue and promoting a healthy environment for beneficial bacteria to grow.

Can Leaky Gut Be Reversed?

Leaky gut is a condition that occurs when the lining of your small intestines is weakened, allowing toxins and undigested proteins to leak into your bloodstream. This can cause inflammation throughout your body and lead to a wide range of health problems.

The good news is that leaky gut can be reversed—and there’s a lot you can do to help it along! Here are some strategies:

  • Take probiotics: These supplements contain beneficial bacteria to help crowd out the bad bacteria in your digestive tract. They also help boost immunity, which helps boost overall health and prevent future infections from occurring.
  • Eat fermented foods: Foods like kimchi, sauerkraut, and yogurt contain healthy bacteria that will help strengthen your intestinal lining and keep you from experiencing a leaky gut again.
  • Use fish oil: Many people who have experienced leaky gut syndrome have found relief by taking fish oil supplements daily for several months at a time—and this strategy may be especially helpful for those who are trying to reverse their condition naturally rather than through medications like antibiotics or steroids.

How Fast Can You Heal a Leaky Gut?

The speed at which you can heal a leaky gut depends on a number of factors, including your age and the severity of the leaky gut. If you have a mild case of leaky gut, you may be able to heal it in as little as three days.

If you have a more severe case, it could take weeks or even months for your body to start working properly again.


Gut health affects nearly all other bodily functions, because the gut often acts as a gateway for toxins, bacteria, and various other things that wouldn’t normally make it into our system. It can affect digestion, mood, sleep, immune function, weight loss/gain and more.

A good leaky gut supplement should be effective and safe for you to take. It can also help to have a natural way to heal your digestive system as you try to improve the immune system.

Research has shown that some supplements are able to reduce the risk of healing an autoimmune condition. Healing leaky gut naturally is difficult, but it can be done with enough research and dedication.

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